NEW Wautoma Biotech Inlne Dilution System

Next Generation Single-Use Inline Dilution System

Precise, Streamlined Buffer Preparation and Delivery — Powered by Digital Blending

In today’s fast-paced biopharmaceutical manufacturing landscape, the Wautoma Biotech single-use inline dilution (ILD) system offers a cost-effective and efficient alternative to traditional buffer preparation and management. Traditional processes require manually preparing and storing large quantities of buffers, which is both time-consuming and space-intensive. By contrast, the Wautoma Biotech ILD system enables on-demand buffer preparation and precise delivery at the point of use, seamlessly integrating downstream processes. This streamlined approach minimizes labor and space requirements while improving process efficiency and reducing operator error.

The latest generation of the Wautoma Biotech ILD system now integrates Wautoma Digital Blending—a next-generation control architecture that moves beyond conventional ratio control with pulse-based volumetric synchronization. The result is a system that doesn’t just command the right flow—it verifies and corrects it in real time, delivering superior process stability across every run.

The Single-Use Inline Dilution System delivers practical solutions for biopharmaceutical manufacturers seeking to optimize processes, reduce costs, and achieve reliable, high-quality results in a streamlined, efficient manner.

Wautoma Digital Blending: A Next-Generation Control Architecture

The latest Wautoma ILD system moves beyond conventional ratio control with a fundamentally different approach to multi-stream synchronization: Wautoma Digital Blending.

Traditional ratio control assumes that pumps, sensors, and tubing behave exactly as commanded. In practice, they don’t. Pumps drift. Tubing wears. Sensors experience noise. Even when each component remains within specification, the cumulative effect of small variations can shift final solution composition away from the intended target—often going undetected until the batch is already complete.

Wautoma Digital Blending addresses this at the architectural level. Rather than relying solely on commanded flow rates, the system synchronizes all process streams using verified volumetric transfer. Every secondary stream references a common volumetric truth source, allowing the system to continuously adapt to real-world process conditions—correcting drift rather than accumulating it.

Key Capabilities of Digital Blending

  • Pulse-based volumetric synchronization across all streams
  • Per-scan error closure (every ~100 ms) prevents drift from building
  • Inline PAT feedback for real-time concentration trim
  • Dynamic ramp-up/ramp-down intelligence for precise low-flow control
  • Automatic pacing detection to maintain blend ratio under hardware limits
  • User-configurable ratio and recipe management

What This Means for Your Process

  • Sub-percent concentration accuracy (±0.25–0.50% volumetric; ±0.05–0.10% with trim enabled)
  • Zero drift—short runs, long campaigns, and multi-bag operations alike
  • Reduced startup waste: only the physical volume in the flow path, not ratio stabilization time
  • Continuous out-of-spec detection with automatic waste diversion
  • Stable, reproducible performance under peristaltic pulsation, tubing elasticity, and flow meter variation

For a deeper look at why Digital Blending outperforms conventional ratio control in modern bioprocessing—and what the data shows—read our blog: “Why Ratio Control Is No Longer Enough for Modern Bioprocessing.”

Discover the Benefits of the Single-Use Inline Dilution System

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Streamlined Buffer Preparation

The ILD system prepares buffers on demand through an integrated single-use mixer, eliminating the need for extensive buffer preparation and storage. This approach accelerates production timelines and optimizes workflow.
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Precise and Just-in-Time Delivery

The system ensures accurate dilution and delivery of highly concentrated buffer solutions directly to the point of use in your process, enhancing reliability and process control.
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Improved Resource Efficiency

By automating buffer preparation, the ILD system optimizes the use of labor, reagents, and facility space, reducing operational costs.
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Superior Process Consistency with Digital Blending

The ILD system leverages Wautoma Digital Blending to continuously verify and correct stream ratios in real time, eliminating the drift and variability inherent in conventional ratio control approaches.
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Reduced Risk of Operator Errors

Automation eliminates manual steps, reducing the potential for errors in buffer preparation and handling, which is particularly critical in biopharmaceutical manufacturing.
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Smaller Facility Footprint

The compact design of the ILD system reduces the need for large buffer storage tanks, freeing up valuable floor space and simplifying infrastructure requirements.
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Support for High-Throughput Processes

Designed for demanding environments, the ILD system integrates efficiently into high-throughput manufacturing workflows, such as those in contract manufacturing organizations (CMOs).
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Sustainability Benefits

By replacing traditional stainless-steel tanks, the system reduces water and energy consumption associated with cleaning and sterilization, contributing to a more sustainable manufacturing process.
Wautoma Inline Dilution

Technical Specifications

Feature 1/2″ Tubing 3/4″ Tubing
Maximum Flow Rate 13.3 LPM 20 LPM
Minimum Flow Rate 0.167 LPM 0.167 LPM
Operating Pressure 4 bar (58 psi) 4 bar (58 psi)
pH Range 3-10 pH 3-10 pH
Conductivity Range 0.1-100 mS/cm 0.1-100 mS/cm
Process Temp Range 0-70°C 0-70°C
Ambient Humidity 10-90% (non-cond.) 10-90% (non-cond.)
Utility Power 20 A, 120 VAC 20 A, 120 VAC
Water Inlets 1 Water, 4 Buffer 1 Water, 4 Buffer
Concentrate Inlets Up to 4 Up to 4
Product Outlets 2 2
Flow Measurement Technology  Clamp-On Ultrasonic Clamp-On Ultrasonic
 Sensor Wetted Components None None
 Control Architecture Wautoma Digital Blending Wautoma Digital Blending
 Blending Method Pulse-Base Volumetric Synchronization Pulse-Based Volumetric Synchronization
 Ratio Control User Configurable User Configurable
 Recipe Management Included Included
 Process Monitoring Conductivity and pH Conductivity and pH
 Product Contract Surface Single-Use Flow Path Single-Use Flow Path
 Flow Kit Changeover Tool-Free Tool-Free
 Frame Construction Stainless Steel Mobile Enclosure Stainless Steel Mobile Enclosure
Mobility Locking Caster Locking Caster
Automation Platform Rockwell Automation PLC Rockwell Automation PLC
HMI Platform Ignition® Ignition®
Communications EtherNet/IP EtherNet/IP
Dimensions (WxDxH) 50″ x 50″ x 56″ 50″ x 50″ x 56″

 

Quality Single-Use Consumables Designed Around Your Process

Wautoma Biotech offerss high-quality, user-friendly single-use assemblies designed to meet the rigorous standards of the bioprocessing industry. Partnering with leading manufacturers, we provide assemblies built to cGMP guidelines using only USP Class VI certified materials, ensuring safety and reliability. Each assembly is delivered pre-sterilized through gamma irradiation, ready for immediate use to minimize preparation time and contamination risks.

We collaborate with our clients to create assemblies that reflect specific process requirements, whether choosing fluid contact materials or integrating unique components. Before production, clients review and approve detailed General Assembly (GA) drawings that outline part numbers, descriptions, and technical notes, ensuring that every aspect meets exact specifications. As a specialist and impartial provider of single-use assemblies, Wautoma Biotech is dedicated to delivering solutions that align seamlessly with your operational demands.

Wautoma Biotech single-use flow kit

Wautoma Biotech assemblies include fully sterilized, single-use tubing sets with integrated sensors for streamlined and safe operations. Designed with sterile-to-sterile connections, which reduce contamination risks and support reliable, efficient processes.

Flexible, Standards-Compliant, and Future-Ready Biopharma 4.0 Automation Capabilities

Wautoma bioprocess automation solutions for single-use systems are designed to be flexible and innovative at their core. We offer cloud-based Biopharma 4.0 automation and also enable seamless integration with the industry’s leading automation platforms, giving you the freedom to choose the best fit for your bioprocess. Whether you rely on DeltaV®, Rockwell Automation®, or another modern control system, our products are engineered to interface effortlessly with your preferred platform while fully adhering to ISA-88 batch-compliant standards.

Our forward-looking approach to bioprocess automation embraces the latest advancements, including cloud-based solutions that seamlessly integrate with your operations. This commitment to Biopharma 4.0 not only enhances productivity but also helps to reduce costs and strengthen compliance, ensuring that your automation solution is equipped to meet the demands of both today and tomorrow.

Our configurable single-use product designs also let you choose between manual, semi-automated, or fully automated operation, allowing the system to evolve alongside your processes and meet your specific needs as they grow.

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A Lasting Partnership for the Full Product Lifecycle

At Wautoma Biotech, our commitment to our customers extends far beyond design, manufacturing, testing, installation, and validation. We remain an active partner throughout the entire lifecycle of your product, providing ongoing support and maintenance to ensure optimal performance. Our team is dedicated to assisting with any challenges that arise, offering upgrades and enhancements as needed to keep pace with advancements in technology and evolving industry standards. By staying closely aligned with your operational needs over time, we help you maximize the value of your investment and maintain reliable performance every step of the way.
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